Biofizika İnstitutunda “Bioelektrik Siqnal Şəbəkəsinin (Network) Formalaşmasının Molekulyar-struktur Əsasları” mövzusunda elmi seminar keçiriləcək

03 may 2024-cü il tarixində saat 14:30-da Azərbaycan Respublikası Elm və Təhsil Nazirliyinin Biofizika İnstitutunda “Bioelektrik Siqnal Şəbəkəsinin (Network) Formalaşmasının Molekulyar-struktur Əsasları” mövzusunda elmi seminar keçiriləcəkdir. Seminarda Hüceyrə siqnalının otürülməsi laboratoriyasının müdiri, b.ü.f.d., dos. Taleh Yusifov çıxış edəcəkdir.

Xahiş edirəm seminarda iştirak edəsiniz.

Qısa məlumat:

The Molecular Structural Basis for the Formation Bioelectrical Signaling Network

Recent studies have reported that ion channels, related to their function of bioelectrical signals are involved in the regulation of the cell cycle and proliferation. Specifically, the human BK channels play a fundamental role in disorders of various types of cancer cells, including triple-negative breast cancer cells, neuroblastoma cells, glioblastoma, and human astrocytoma cells. Therefore, BK channels are targeted to fight cancer. While BK channel modulation by Ca bears intriguing physiological significance underlying mechanism ultimately leading to regulation of the ion conduction gate remains unknown.

To resolve the early molecular events underlying Ca-mediated BK modulation and to understand how the BK channel discriminates among a multitude of cytosolic ligands, we are applying a combination of biochemical and spectroscopic techniques on the purified human GR under physiologically relevant conditions.

Thus, we have demonstrated that the BK gating ring operates as a selective chemo-mechanical coupler that transduces the free energy of ligand binding into mechanical work that ultimately activates the channel.

01 May 2024

Paylaş