A scientific seminar will be held at the Institute of Biophysics on "Molecular-structural Basis of the Formation of the Bioelectrical Signaling Network"

On May 3, 2024, at 14:30, a scientific seminar on "Molecular Structure Basis of the Formation of the Bioelectric Signal Network" will be held at the Institute of Biophysics of the MSE AR. The seminar will feature a presentation by the head of the Cell Signaling Laboratory, Ph.D. Taleh Yusifov.

Please attend the seminar.

Short information:

The Molecular Structural Basis for the Formation Bioelectrical Signaling Network

Recent studies have reported that ion channels, related to their function of bioelectrical signals are involved in the regulation of the cell cycle and proliferation. Specifically, the human BK channels play a fundamental role in disorders of various types of cancer cells, including triple-negative breast cancer cells, neuroblastoma cells, glioblastoma, and human astrocytoma cells. Therefore, BK channels are targeted to fight cancer. While BK channel modulation by Ca bears intriguing physiological significance underlying mechanism ultimately leading to regulation of the ion conduction gate remains unknown.

To resolve the early molecular events underlying Ca-mediated BK modulation and to understand how the BK channel discriminates among a multitude of cytosolic ligands, we are applying a combination of biochemical and spectroscopic techniques on the purified human GR under physiologically relevant conditions.

Thus, we have demonstrated that the BK gating ring operates as a selective chemo-mechanical coupler that transduces the free energy of ligand binding into mechanical work that ultimately activates the channel.

01 May 2024

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