A scientific seminar on " Search for conservative HER2 motifs - epitope design for therapeutically important humanized monoclonal antibodies " will be held at the Institute of Biophysics.

On May 23, 2024 at 15:00 at the Institute of Biophysics of the Ministry of Science and Education of the Republic of Azerbaijan, a scientific seminar on "Search for conservative HER2 motifs - epitope design for therapeutically important humanized monoclonal antibodies" will be held. At the seminar, the head of the "Molecular and cellular biochemistry" laboratory of the Institute of Biophysics, Ph.D Karim Gasimov will speak.

Please attend the seminar.

Brief information:

Overexpression of human epidermal growth factor receptor 2 (HER2) is associated with tumor aggressiveness and poor prognosis in breast (as well as lung) cancer. With the availability of therapeutic antibodies against HER2, great advances have been made in the clinical management of HER2-positive breast cancer. However, de nova and acquired resistance to these antibodies face a serious limitation for successful HER2-targeted therapy. The identification of new epitopes of HER2 that can be used for functional and region-specific blockade may be a central step in the development of new clinically relevant anti-HER2 antibodies. The evolutionarily conserved motifs of the extracellular domain of HER2 (ECD HER2) contain potentially therapeutically important epitopes/targets.

Given that structural and linear conservative motifs can provide functionally specific configurations, it is suggested that additional medicinally important epitopes/targets may be identified in the ECD HER2 protein, which may allow modifications for potential therapeutic application.

20 May 2024

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